Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload.

ABSTRACT:

Background

The mitochondrial unfolded protein response (UPR^mt) is activated when misfolded proteins accumulate within mitochondria and leads to increased expression of mitochondrial chaperones and proteases to maintain protein quality and mitochondrial function. Cardiac mitochondria are essential for contractile function and regulation of cell viability, while mitochondrial dysfunction characterizes heart failure. The role of the UPR^mt in the heart is unclear.

Objectives

The purpose of this study was to: 1) identify conditions that activate the UPR^mt in the heart; and 2) study the relationship among the UPR^mt, mitochondrial function, and cardiac contractile function.

Methods

Cultured cardiac myocytes were subjected to differ

SUBMITTER: Smyrnias I 

PROVIDER: S-EPMC6456800 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature