Global Lysine Acetylation in Escherichia coli Results from Growth Conditions That Favor Acetate Fermentation.

ABSTRACT: Lysine acetylation is thought to provide a mechanism for regulating metabolism in diverse bacteria. Indeed, many studies have shown that the majority of enzymes involved in central metabolism are acetylated and that acetylation can alter enzyme activity. However, the details regarding this regulatory mechanism are still unclear, specifically with regard to the signals that induce lysine acetylation. To better understand this global regulatory mechanism, we profiled changes in lysine acetylation during growth of Escherichia coli on the hexose glucose or the pentose xylose at both high and low sugar concentrations using label-free mass spectrometry. The goal was to see whether lysine acetylation differed during growth on these two different sugars. No significant differences, however, were o

SUBMITTER: Schilling B 

PROVIDER: S-EPMC6456854 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature