TRNA Modification Profiles and Codon-Decoding Strategies in Methanocaldococcus jannaschii.

ABSTRACT: tRNAs play a critical role in mRNA decoding, and posttranscriptional modifications within tRNAs drive decoding efficiency and accuracy. The types and positions of tRNA modifications in model bacteria have been extensively studied, and tRNA modifications in a few eukaryotic organisms have also been characterized and localized to particular tRNA sequences. However, far less is known regarding tRNA modifications in archaea. While the identities of modifications have been determined for multiple archaeal organisms, Haloferax volcanii is the only organism for which modifications have been extensively localized to specific tRNA sequences. To improve our understanding of archaeal tRNA modification patterns and codon-decoding strategies, we have used liquid chromatography and tandem mass sp

SUBMITTER: Yu N 

PROVIDER: S-EPMC6456858 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature