The Response of nor and nos Contributes to Staphylococcus aureus Virulence and Metabolism.

ABSTRACT: Staphylococcus aureus causes a wide spectrum of disease, with the site and severity of infection dependent on virulence traits encoded within genetically distinct clonal complexes (CCs) and bacterial responses to host innate immunity. The production of nitric oxide (NO) by activated phagocytes is a major host response to which S. aureus metabolically adapts through multiple strategies that are conserved in all CCs, including an S. aureus nitric oxide synthase (Nos). Previous genome analysis of CC30, a lineage associated with chronic endocardial and osteoarticular infections, revealed a putative NO reductase (Nor) not found in other CCs that potentially contributes to NO resistance and clinical outcome. Here, we demonstrate that Nor has true nitric oxide reductase activ

SUBMITTER: Favazzo LJ 

PROVIDER: S-EPMC6456865 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature