The rational simplification of a recombinant cocktail vaccine to control the parasitic nematode Teladorsagia circumcincta.

ABSTRACT: Using data from five independent vaccine trials, which employed a subunit cocktail vaccine containing eight recombinant proteins to protect sheep against Teladorsagia circumcincta, a strategy was developed to simplify antigen complexity of the vaccine. A meta-analysis of data from these five trials demonstrated statistically significant reductions in cumulative faecal egg count and worm burden in vaccinated sheep when compared with those which had received adjuvant only (P = 0.009 and P < 0.0001, respectively). Relationships between antigen-specific antibody levels, antibody avidity and parasitological parameters of efficacy were analysed for each of the eight proteins in these trials. Of these, the strongest correlations between percentage reduction in cumulative faecal egg count and avid

SUBMITTER: Nisbet AJ 

PROVIDER: S-EPMC6456928 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature