Metabolomics Identifies Distinctive Metabolite Signatures for Measures of Glucose Homeostasis: The Insulin Resistance Atherosclerosis Family Study (IRAS-FS).

ABSTRACT:

Context

Metabolomics provides a biochemical fingerprint that, when coupled with clinical phenotypes, can provide insight into physiological processes.

Objective

Survey metabolites associated with dynamic and basal measures of glucose homeostasis.

Design

Analysis of 733 plasma metabolites from the Insulin Resistance Atherosclerosis Family Study.

Setting

Community based.

Participants

One thousand one hundred eleven Mexican Americans.

Main outcome

Dynamic measures were obtained from the frequently sampled intravenous glucose tolerance test and included insulin sensitivity and acute insulin response to glucose. Basal measures included homeostatic model assessment of insulin resistance and β-cell function.

Results

Insulin sensitivity was associa

SUBMITTER: Palmer ND 

PROVIDER: S-EPMC6456957 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature