Differential methylation in rare ophthalmic disorders: a systematic review protocol.

ABSTRACT:

Background

Rare ophthalmic conditions often cause degenerative vision loss which leads to loss of independence, ability to work and ultimately quality life. Differential methylation is an epigenomic marker that is a feature of several diseases, including eye conditions. This review will aim to elucidate the extent to which differential methylation has been identified in rare ophthalmic conditions.

Methods

A systematic review will be conducted of articles found in the electronic databases MEDLINE, EMBASE, PubMed and Cochrane Library of Systematic Reviews. Grey literature databases GreyLit and OpenGrey will be searched for relevant unpublished sources. Reference lists of articles which meet eligibility criteria will also be screened for forward and reverse citations. Eligibili

SUBMITTER: Kerr K 

PROVIDER: S-EPMC6456967 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature