Role of Kisspeptin and Neurokinin B Signaling in Male Rhesus Monkey Puberty.

ABSTRACT: Despite the well-established concept that an increase in pulsatile GnRH release triggers puberty, the precise signaling mechanism responsible for the pubertal increase in GnRH release remains unclear. A recent study indicates that developmental changes in the network formation between kisspeptin and neurokinin B (NKB) signaling greatly contribute to the pubertal increase in GnRH release in female monkeys. It is, however, unknown whether similar developmental changes in the kisspeptin and NKB network are involved in male puberty. In the current study, we first characterized the pubertal stages in male rhesus monkeys by assessing physiological and hormonal changes during sexual development. Subsequently, we examined the role of the kisspeptin and NKB signaling network in the pubertal increas

SUBMITTER: Garcia JP 

PROVIDER: S-EPMC6456982 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature