Randomized Trial of CPAP and Vardenafil on Erectile and Arterial Function in Men With Obstructive Sleep Apnea and Erectile Dysfunction.

ABSTRACT:

Context

Erectile function is important for life satisfaction and often impaired in men with obstructive sleep apnea (OSA). Uncontrolled studies show that treating OSA with continuous positive airway pressure (CPAP) improves erectile function. Phosphodiesterase type 5 inhibitors (e.g., vardenafil) are the first-line therapy for erectile dysfunction (ED), but may worsen OSA.

Objective

To assess the effects of CPAP and vardenafil on ED.

Design

Sixty-one men with moderate-to-severe OSA and ED were randomized to 12 weeks of CPAP or sham CPAP, and 10 mg daily vardenafil or placebo in a two-by-two factorial design.

Main outcome measures

International Index of Erectile Function (primary end point), treatment and relationship satisfaction, sleep-related erections, sexua

SUBMITTER: Melehan KL 

PROVIDER: S-EPMC6457007 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature