Significance of Complement System in Ischemic Stroke: A Comprehensive Review.

ABSTRACT: The complement system is an essential part of innate immunity, typically conferring protection via eliminating pathogens and accumulating debris. However, the defensive function of the complement system can exacerbate immune, inflammatory, and degenerative responses in various pathological conditions. Cumulative evidence indicates that the complement system plays a critical role in the pathogenesis of ischemic brain injury, as the depletion of certain complement components or the inhibition of complement activation could reduce ischemic brain injury. Although multiple candidates modulating or inhibiting complement activation show massive potential for the treatment of ischemic stroke, the clinical availability of complement inhibitors remains limited. The complement system is also involved

SUBMITTER: Ma Y 

PROVIDER: S-EPMC6457046 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature