Lithium treatment, nephrogenic diabetes insipidus and the risk of hypernatraemia: a retrospective cohort study.

ABSTRACT:

Background

Hypernatraemia is a serious condition that can potentially become life threatening. It is known that lithium is associated with polyuria and nephrogenic diabetes insipidus, risk factors for hypernatraemia. In this study, we tested the hypothesis that lithium treatment was a risk factor for hypernatraemia.

Methods

We performed a retrospective cohort study in the Swedish region of Norrbotten into the effects and potential adverse effects of lithium treatment and other mood stabilizers (LiSIE). For this particular study, we included all patients who had experienced at least one episode with a sodium concentration ⩾150 mmol/L between 1997 and 2013. Medical records were reviewed regarding past or current lithium exposure, diabetes insipidus and other potential risk fac

SUBMITTER: Ott M 

PROVIDER: S-EPMC6457074 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature