Plasma acylcarnitines and progression of carotid artery atherosclerosis in HIV infection.

ABSTRACT:

Objective

To evaluate plasma acylcarnitine profiles and their relationships with progression of carotid artery atherosclerosis among individuals with and without HIV infection.

Design

Prospective cohort studies of 499 HIV-positive and 206 HIV-negative individuals from the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study.

Methods

Twenty-four acylcarnitine species were measured in plasma samples of participants at baseline. Carotid artery plaque was assessed using repeated B-mode carotid artery ultrasound imaging in 2004-2013. We examined the associations of individual and aggregate short-chain (C2-C7), medium-chain (C8-C14) and long-chain acylcarnitines (C16-C26) with incident carotid artery plaque over 7 years.

Results

Among 24 acylcarnitine

SUBMITTER: Hua S 

PROVIDER: S-EPMC6457128 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature