Differences in the rate of nicotine metabolism among smokers with and without HIV.

ABSTRACT:

Objective

HIV-infected smokers lose more life years to tobacco use than to HIV infection. The nicotine metabolite ratio (NMR), a biomarker of CYP2A6, represents individual variation in the rate at which nicotine is metabolized and is associated with response to smoking cessation treatments. We evaluated whether HIV-infected smokers metabolize nicotine faster than HIV-uninfected smokers, which may contribute to the disproportionate smoking burden and may have important treatment implications.

Design

We analysed baseline data from two clinical trials (NCT01710137; NCT01314001) to compare the NMR in HIV-infected smokers (N = 131) to HIV-uninfected smokers (N = 199).

Methods

Propensity scores were used to match the groups 2 : 1 on characteristics that influence NMR: sex,

SUBMITTER: Ashare RL 

PROVIDER: S-EPMC6457129 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature