Efficacy and immunologic effects of extracorporeal photopheresis plus interleukin-2 in chronic graft-versus-host disease.

ABSTRACT: Chronic graft-versus-host disease (cGVHD) affects >50% of hematopoietic stem cell transplant patients. Extracorporeal photopheresis (ECP), an immunomodulatory therapy, provides clinical benefit in steroid-refractory (SR) cGVHD, possibly via regulatory T (T_reg) and natural killer (NK) cell expansion. We demonstrated that low-dose interleukin-2 (IL2) led to clinical improvement in SR-cGVHD and stimulated preferential T_reg and NK-cell expansion with minimal effect on conventional T (T_con) cells. We evaluated the effect of ECP (weeks 1-16) plus IL2 (1 × 10⁶ IU/m², weeks 9-16) in 25 adult patients with SR-cGVHD in a prospective phase 2 trial. Objective responses occurred in 29% and 62% of evaluable patients at weeks 8 (ECP alone) and 16 (EC

SUBMITTER: Belizaire R 

PROVIDER: S-EPMC6457231 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature