Safety and immune regulatory properties of canine induced pluripotent stem cell-derived mesenchymal stem cells.

ABSTRACT: Mesenchymal stem cells (MSCs) exhibit broad immune modulatory activity in vivo and can suppress T cell proliferation and dendritic cell activation in vitro. Currently, most MSC for clinical usage are derived from younger donors, due to ease of procurement and to the superior immune modulatory activity. However, the use of MSC from multiple unrelated donors makes it difficult to standardize study results and compare outcomes between different clinical trials. One solution is the use of MSC derived from induced pluripotent stem cells (iPSC); as iPSC-derived MSC have nearly unlimited proliferative potential and exhibit in vitro phenotypic stability. Given the value of dogs as a spontaneous disease model for pre-clinical evaluation of stem cell therapeutics, we investigated the functional prop

SUBMITTER: Chow L 

PROVIDER: S-EPMC6457437 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature