Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer.

ABSTRACT:

Purpose

The lack of a molecular target in triple-negative breast cancer (TNBC) makes it one of the most challenging breast cancers to treat. Radiation therapy (RT) is an important treatment modality for managing breast cancer; however, we previously showed that RT can also reprogram a fraction of the surviving breast cancer cells into breast cancer-initiating cells (BCICs), which are thought to contribute to disease recurrence. In this study, we characterize mebendazole (MBZ) as a drug with potential to prevent the occurrence of radiation-induced reprogramming and improve the effect of RT in patients with TNBC.

Methods and materials

A high-throughput screen was used to identify drugs that prevented radiation-induced conversion of TNBC cells into cells with a cancer-initiatin

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6457649 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature