Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases.

ABSTRACT:

Background

The benefits of adding upfront whole-brain radiotherapy (WBRT) to surgery or stereotactic radiosurgery (SRS) when compared to surgery or SRS alone for treatment of brain metastases are unclear.

Objectives

To compare the efficacy and safety of surgery or SRS plus WBRT with that of surgery or SRS alone for treatment of brain metastases in patients with systemic cancer.

Search methods

We searched MEDLINE, EMBASE and The Cochrane Central Register of Controlled Trials (CENTRAL) up to May 2013 and annual meeting proceedings of ASCO and ASTRO up to September 2012 for relevant studies.

Selection criteria

Randomised controlled trials (RCTs) comparing surgery or SRS plus WBRT with surgery or SRS alone for treatment of brain metastases.

Data collection and a

SUBMITTER: Soon YY 

PROVIDER: S-EPMC6457788 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature