Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid.

ABSTRACT: Diffuse gliomas are the most common malignant brain tumours in adults and include glioblastomas and World Health Organization (WHO) grade II and grade III tumours (sometimes referred to as lower-grade gliomas). Genetic tumour profiling is used to classify disease and guide therapy^1,2, but involves brain surgery for tissue collection; repeated tumour biopsies may be necessary for accurate genotyping over the course of the disease^3-10. While the detection of circulating tumour DNA (ctDNA) in the blood of patients with primary brain tumours remains challenging^11,12, sequencing of ctDNA from the cerebrospinal fluid (CSF) may provide an alternative way to genotype gliomas with lower morbidity and cost^13,14. We therefore evaluated the representation of

SUBMITTER: Miller AM 

PROVIDER: S-EPMC6457907 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature