A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.

ABSTRACT: DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. Although biochemical mechanisms for repairing several forms of genomic insults are well understood, the upstream signalling pathways that trigger repair are established for only certain types of damage, such as double-stranded breaks and interstrand crosslinks. Understanding the upstream signalling events that mediate recognition and repair of DNA alkylation damage is particularly important, since alkylation chemotherapy is one of the most widely used systemic modalities for cancer treatment and because environmental chemicals may trigger DNA alkylation. Here we demonstrate that human cells have a

SUBMITTER: Brickner JR 

PROVIDER: S-EPMC6458054 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature