Ontology highlight
ABSTRACT:
SUBMITTER: Kubota S
PROVIDER: S-EPMC6458132 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Nature communications 20190410 1
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive subtype of acute leukemia, the cell of origin of which is considered to be precursors of plasmacytoid dendritic cells (pDCs). Since translocation (6;8)(p21;q24) is a recurrent anomaly for BPDCN, we demonstrate that a pDC-specific super-enhancer of RUNX2 is associated with the MYC promoter due to t(6;8). RUNX2 ensures the expression of pDC-signature genes in leukemic cells, but also confers survival and proliferative properties ...[more]