Pathway centrality in protein interaction networks identifies putative functional mediating pathways in pulmonary disease.

ABSTRACT: Identification of functional pathways mediating molecular responses may lead to better understanding of disease processes and suggest new therapeutic approaches. We introduce a method to detect such mediating functions using topological properties of protein-protein interaction networks. We define the concept of pathway centrality, a measure of communication between disease genes and differentially expressed genes. Using pathway centrality, we identify mediating pathways in three pulmonary diseases (asthma; bronchopulmonary dysplasia (BPD); and chronic obstructive pulmonary disease (COPD)). We systematically evaluate the significance of all identified central pathways using genetic interactions. Mediating pathways shared by all three pulmonary disorders favor innate immune and inflammation

SUBMITTER: Park J 

PROVIDER: S-EPMC6458310 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature