Linking dynamical complexities from activation signals to transcription responses.

ABSTRACT: The transcription of inducible genes involves signalling pathways that induce DNA binding of the downstream transcription factors to form functional promoter states. How the transcription dynamics is linked to the temporal variations of activation signals is far from being fully understood. In this work, we develop a mathematical model with multiple promoter states to address this question. Each promoter state has its own activation and inactivation rates and is selected randomly with a probability that may change in time. Under the activation of constant signals, our analysis shows that if only the activation rates differ among the promoter states, then the mean transcription level m(t) displays only a monotone or monophasic growth pattern. In a sharp contrast, if the inacti

SUBMITTER: Lin G 

PROVIDER: S-EPMC6458353 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature