?1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis.

ABSTRACT: Syntrophins are a family of proteins forming membrane-anchored scaffolds and serving as adaptors for various transmembrane and intracellular signaling molecules. To understand the physiological roles of ?1 syntrophin, one of the least characterized members, we generated mouse models to eliminate ?1 syntrophin specifically in the endocrine or exocrine pancreas. ?1 syntrophin is dispensable for the morphology and function of insulin-producing ? cells. However, mice with ?1 syntrophin deletion in exocrine acinar cells exhibit increased severity of cerulein-induced acute pancreatitis. Reduced expression of cystic fibrosis transmembrane conductance regulator and dilation of acinar lumen are potential predisposition factors. During the disease progression, a relative lack of autophagy is associated with deficiencies in both actin assembly and endoplasmic reticulum nucleation. Our findings reveal, for the first time, that ?1 syntrophin is a critical regulator of actin cytoskeleton and autophagy in pancreatic acinar cells and is potently protective against cerulein-induced acute pancreatitis.

SUBMITTER: Ye R 

PROVIDER: S-EPMC6458522 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature