Fasciola Hepatica Isolates Induce Different Immune Responses in Unmaturated Bovine Macrophages.

ABSTRACT:

Introduction

Fasciola hepatica (liver fluke) is a parasite of great socioeconomic importance. A number of fluke isolates have been identified; however, to date the differences between the immunomodulatory properties of different parasite isolates have not been sufficiently investigated. The aim of this study was to explore differences between the immunomodulatory properties of two F. hepatica isolates using unmaturated bovine macrophages.

Material and methods

A cell line of bovine macrophages was stimulated with excretory/secretory products released by adult flukes from either a laboratory (Fh-WeyES) or wild (Fh-WildES) strain and subsequently subjected to microarray and ELISA analyses. Results: Both Fh-WeyES and Fh-WildES dam

SUBMITTER: Baska P 

PROVIDER: S-EPMC6458565 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature