Fibroblast growth factor 23, endothelium biomarkers and acute kidney injury in critically-ill patients.

ABSTRACT:

Background

Fibroblast growth factor 23 (FGF23) and endothelium-related biomarkers have been related to AKI in critically-ill patients. Also, FGF23 is associated with endothelial dysfunction. In this study, we investigated if elevated FGF23 association with severe AKI is mediated by several endothelial/glycocalyx-related biomarkers.

Methods

Prospective cohort study with critically-ill patients. Blood samples were collected within the first 24 h after ICU admission. Severe AKI (defined according to KDIGO stage 2/3) was the analyzed outcome.

Results

265 patients were enrolled and 82 (30.9%) developed severe AKI-defined according to KDIGO stage 2/3. Blood samples to biomarkers measurement were collected within the first 24 h after ICU admission. After adjustment for sever

SUBMITTER: de Oliveira Neves FM 

PROVIDER: S-EPMC6458699 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature