Salicylic acid amplifies Carbachol-induced bronchoconstriction in human precision-cut lung slices.

ABSTRACT:

Background

Asthma exacerbations evoke emergency room visits, progressive loss of lung function and increased mortality. Environmental and industrial toxicants exacerbate asthma, although the underlying mechanisms are unknown. We assessed whether 3 distinct toxicants, salicylic acid (SA), toluene diisocyanate (TDI), and 1-chloro-2,4-dinitrobenzene (DNCB) induced airway hyperresponsiveness (AHR) through modulating excitation-contraction coupling in human airway smooth muscle (HASM) cells. The toxicants include a non-sensitizing irritant (SA), respiratory sensitizer (TDI) and dermal sensitizer (DNCB), respectively. We hypothesized that these toxicants induce AHR by modulating excitation-contraction (EC) coupling in airway smooth muscle (ASM) cells.

Methods

Carbachol-induced bro

SUBMITTER: Jude J 

PROVIDER: S-EPMC6458705 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature