Reduced FRG1 expression promotes prostate cancer progression and affects prostate cancer cell migration and invasion.

ABSTRACT:

Background

Prostate cancer is the most common form of cancer in males and accounts for high cancer related deaths. Therapeutic advancement in prostate cancer has not been able to reduce the mortality burden of prostate cancer, which warrants further research. FRG1 which affects angiogenesis and cell migration in Xenopus, can be a potential player in tumorigenesis. In this study, we investigated the role of FRG1 in prostate cancer progression.

Methods

Immunohistochemistry was performed to determine FRG1 expression in patient samples. FRG1 expression perturbation was done to investigate the effect of FRG1 on cell proliferation, migration and invasion, in DU145, PC3 and LNCaP cells. To understand the mechanism, we checked expression of various cytokines and MMPs by q-RT PCR, si

SUBMITTER: Tiwari A 

PROVIDER: S-EPMC6458714 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature