Identification of monotonically differentially expressed genes for non-small cell lung cancer.

ABSTRACT:

Background

Monotonically expressed genes (MEGs) are genes whose expression values increase or decrease monotonically as a disease advances or time proceeds. Non-small cell lung cancer (NSCLC) is a multistage progression process resulting from genetic sequences mutations, the identification of MEGs for NSCLC is important.

Results

With the aid of a feature selection algorithm capable of identifying MEGs - the MFSelector method - two sets of potential MEGs were selected in this study: the MEGs across the different pathologic stages and the MEGs across the risk levels of death for the NSCLC patients at early stages. For the lung adenocarcinoma (AC) subtypes no statistically significant MEGs were identified across pathologic stages, however dozens of MEGs were identified across t

SUBMITTER: Tian S 

PROVIDER: S-EPMC6458730 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature