Is exposure to tobacco associated with extrahepatic cholangiocarcinoma epidemics? A retrospective proportional mortality study in China.

ABSTRACT:

Background

Extrahepatic cholangiocarcinoma (ECC) has become one of the most rapidly increasing malignancies in China during recent decades. The relationship between tobacco exposure and ECC epidemics is unclear; this study aimed to explore this relationship.

Methods

We included 55,806 participants aged 30 years or older from the National Mortality and Smoking Survey of China. Smoking in participants and spouses was defined as 1 cigarette or more per day for up to 1 year. Spouses' smoking was taken as a measure of exposure to passive smoking. Smoking information in 1980 was ascertained and outcomes were defined as ECC mortality during 1986-1988.

Results

We found that either passive or active smoking increased the risk of death from ECC by 20% (risk ratio [RR], 1.20; 95

SUBMITTER: Hou L 

PROVIDER: S-EPMC6458766 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature