Effect of N-acetylcysteine on exacerbations of bronchiectasis (BENE): a randomized controlled trial.

ABSTRACT:

Background

N-acetylcysteine is a classic mucolytic agent. This study aimed to investigate the efficacy of N-acetylcysteine on reducing the risk of exacerbations in bronchiectasis patients.

Methods

A prospective, randomized, controlled trial was conducted between April 1, 2014 and December 31, 2016 in five general hospitals in Shandong Province, China. Adult bronchiectasis patients with at least two exacerbations in the past year were potentially eligible. Patients were randomly assigned to receive oral N-acetylcysteine (600 mg, twice daily, 12 months) or on-demand treatment.

Results

A total of 161 patients were eligible for randomization (81 to the N-acetylcysteine group and 80 to the control group). During the 12-month follow-up, the incidence of exacerbations in the

SUBMITTER: Qi Q 

PROVIDER: S-EPMC6458826 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature