Functional role of SGK3 in PI3K/Pten driven liver tumor development.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of PI3K catalytic subunit alpha (PIK3CA) and/or loss of Pten often occur in human HCCs. Serum and glucocorticoid kinase 3 (SGK3) belongs to the SGK family of AGK kinases and functions in parallel to AKT downstream of PI3K. Previous studies have shown that SGK3 may be the major kinase responsible for the oncogenic potential of PIK3CA helical domain mutants, such as PIK3CA(E545K), but not kinase domain mutants, such as PIK3CA(H1047R).

Methods

We investigated the functional contribution of SGK3 in mediating activated PIK3CA mutant or loss of Pten induced HCC devel

SUBMITTER: Cao H 

PROVIDER: S-EPMC6458829 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature