Nuclear Imaging of Glucose Metabolism: Beyond ¹⁸F-FDG.

ABSTRACT: Glucose homeostasis plays a key role in numerous fundamental aspects of life, and its dysregulation is associated with many important diseases such as cancer. The atypical glucose metabolic phenomenon, known as the Warburg effect, has been recognized as a hallmark of cancer and serves as a promising target for tumor specific imaging. At present, 2-deoxy-2-[¹⁸F]fluoro-glucose (¹⁸F-FDG)-based positron emission tomography/computed tomography (PET/CT) represented the state-of-the-art radionuclide imaging technique for this purpose. The powerful impact of ¹⁸F-FDG has prompted intensive research efforts into other glucose-based radiopharmaceuticals for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging. Currently, gl

SUBMITTER: Feng H 

PROVIDER: S-EPMC6458935 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature