Comparison of Biphasic vs Static Oxygen Saturation Targets Among Infants With Retinopathy of Prematurity.

ABSTRACT:

Importance

The Surfactant, Positive Pressure, and Pulse Oximetry Randomized Trial (SUPPORT) demonstrated that static low oxygen saturation decreased retinopathy of prematurity (ROP) but increased mortality compared with static high oxygen saturation cohorts.

Objective

To compare outcomes of a biphasic oxygen protocol with static targets recommended by SUPPORT.

Design, setting, and participants

Retrospective cohort study comparing biphasic vs static standards 41 months prior to and 42 months after a change from biphasic to static SUPPORT standards at a level III neonatal intensive care unit (Fairview Hospital, Cleveland, Ohio). The study included infants born at a corrected gestational age (CGA) of 31 weeks or younger or birth weight 1500 g or less. Data were analyzed

SUBMITTER: Shukla A 

PROVIDER: S-EPMC6459099 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature