Prevalence of Germline Variants in Prostate Cancer and Implications for Current Genetic Testing Guidelines.

ABSTRACT:

Importance

Prostate cancer is the third leading cause of cancer-related death in men in the United States. Although serious, most of these diagnoses are not terminal. Inherited risk for prostate cancer is associated with aggressive disease and poorer outcomes, indicating a critical need for increased genetic screening to identify disease-causing variants that can pinpoint individuals at increased risk for metastatic castration-resistant prostate cancer.

Objective

To identify positive (pathogenic, likely pathogenic, and increased risk) germline variants in a large prostate cancer cohort and to evaluate the usefulness of current practice guidelines in recognizing individuals at increased risk for prostate cancer who would benefit from diagnostic genetic testing.

Design, set

SUBMITTER: Nicolosi P 

PROVIDER: S-EPMC6459112 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature