Therapeutic Options for Neuroendocrine Tumors: A Systematic Review and Network Meta-analysis.

ABSTRACT:

Importance

Multiple therapies are currently available for patients with neuroendocrine tumors (NETs), yet many therapies have not been compared head-to-head within randomized clinical trials (RCTs).

Objective

To assess the relative safety and efficacy of therapies for NETs.

Data sources

PubMed, Embase, the Cochrane Central Register of Controlled Trials, trial registries, meeting abstracts, and reference lists from January 1, 1947, to March 2, 2018, were searched. Key search terms included neuroendocrine tumors, gastrointestinal neoplasms, therapy, and randomized controlled trial.

Study selection

Randomized clinical trials comparing 2 or more therapies in patients with NETs (primarily gastrointestinal and pancreatic) were evaluated. Thirty RCTs met the selection

SUBMITTER: Kaderli RM 

PROVIDER: S-EPMC6459123 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature