Prediction Tools for Psychiatric Adverse Effects After Levetiracetam Prescription.

ABSTRACT:

Importance

Levetiracetam is a commonly used antiepileptic drug, yet psychiatric adverse effects are common and may lead to treatment discontinuation.

Objective

To derive prediction models to estimate the risk of psychiatric adverse effects from levetiracetam use.

Design, setting, and participants

Retrospective open cohort study. All patients meeting the case definition for epilepsy after the Acceptable Mortality Reporting date in The Health Improvement Network (THIN) database based in the United Kingdom (inclusive January 1, 2000, to May 31, 2012) who received a first-ever prescription for levetiracetam were included. Of 11 194 182 patients registered in THIN, this study identified 7400 presumed incident cases (66.1 cases per 100 000 persons) over a maximum of 12 year

SUBMITTER: Josephson CB 

PROVIDER: S-EPMC6459128 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature