Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels.

ABSTRACT: Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). Yet evidence from clinical studies indicates that intracellular concentrations of androgens (particularly in androgen-sensitive tissues) are essentially independent of circulating levels. To assess the clinical significance of modest elevations in serum DHT and the DHT/testosterone (T) ratio observed in response to common T replacement therapy, a comprehensive review of the published literature was performed to identify relevant data. Although the primary focus of this review is about DHT in men, we also provide a brief overview of DHT in women

SUBMITTER: Swerdloff RS 

PROVIDER: S-EPMC6459338 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature