Ontology highlight
ABSTRACT:
SUBMITTER: Chen ST
PROVIDER: S-EPMC6459718 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cell host & microbe 20190319 4
Establishing the balance between positive and negative innate immune mechanisms is crucial for maintaining homeostasis. Here we uncover the regulatory crosstalk between two previously unlinked innate immune receptor families: RIG-I, an anti-viral cytosolic receptor activated type I interferon production, and NLR (nucleotide-binding domain, leucine repeat domain-containing protein). We show that NLRP12 dampens RIG-I-mediated immune signaling against RNA viruses by controlling RIG-I's association ...[more]