Dissecting Brain Networks Underlying Alcohol Binge Drinking Using a Systems Genomics Approach.

ABSTRACT: Alcohol use disorder (AUD) is a complex psychiatric disorder with strong genetic and environmental risk factors. We studied the molecular perturbations underlying risky drinking behavior by measuring transcriptome changes across the neurocircuitry of addiction in a genetic mouse model of binge drinking. Sixteen generations of selective breeding for high blood alcohol levels after a binge drinking session produced global changes in brain gene expression in alcohol-naïve High Drinking in the Dark (HDID-1) mice. Using gene expression profiles to generate circuit-level hypotheses, we developed a systems approach that integrated regulation of gene coexpression networks across multiple brain regions, neuron-specific transcriptional signatures, and knowledgebase analytics. Whole-cell, voltage-cla

SUBMITTER: Ferguson LB 

PROVIDER: S-EPMC6459809 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature