Ontology highlight
ABSTRACT:
SUBMITTER: Chakraborty M
PROVIDER: S-EPMC6459870 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Chakraborty Manas M Tarasovetc Ekaterina V EV Zaytsev Anatoly V AV Godzi Maxim M Figueiredo Ana C AC Ataullakhanov Fazly I FI Grishchuk Ekaterina L EL
Nature communications 20190411 1
Accurate chromosome segregation relies on microtubule end conversion, the ill-understood ability of kinetochores to transit from lateral microtubule attachment to durable association with dynamic microtubule plus-ends. The molecular requirements for this conversion and the underlying biophysical mechanisms are elusive. We reconstituted end conversion in vitro using two kinetochore components: the plus end-directed kinesin CENP-E and microtubule-binding Ndc80 complex, combined on the surface of a ...[more]