CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors.

ABSTRACT: The interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. We have recently reported that the outcome of interaction between tumor cells and stromal cells is dependent on the gene expression signature of tumor cells. In the current study, we observed that several cancer cell lines, e.g., MCF7 breast cancer line, exhibited growth advantage when cultured in the presence of conditioned media (CM) derived from human bone marrow stromal stem cells (hBMSCs). Regarding the underlying molecular mechanism, we have identified CXCR7 as highly expressed by MCF7 cells and that it mediated the enhanced growth in response to hBMSC CM. Regarding the clinical relevance, we found an inverse correlation between the level of t

SUBMITTER: Al-Toub M 

PROVIDER: S-EPMC6459874 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature