A Positive Causal Influence of IL-18 Levels on the Risk of T2DM: A Mendelian Randomization Study.

ABSTRACT: A large number of clinical studies have shown that interleukin-18 (IL-18) plasma levels are positively correlated with the pathogenesis and development of type 2 diabetes mellitus (T2DM), but it remains unclear whether IL-18 causes T2DM, primarily due to the influence of reverse causality and residual confounding factors. Genome-wide association studies have led to the discovery of numerous common variants associated with IL-18 and T2DM and opened unprecedented opportunities for investigating possible associations between genetic traits and diseases. In this study, we employed a two-sample Mendelian randomization (MR) method to analyze the causal relationships between IL-18 plasma levels and T2DM using IL18-related SNPs as genetic instrumental variables (IVs). We first selected eight SNPs

SUBMITTER: Zhuang H 

PROVIDER: S-EPMC6459887 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature