Measuring endogenous changes in serotonergic neurotransmission with [¹¹C]Cimbi-36 positron emission tomography in humans.

ABSTRACT: Developing positron emission tomography (PET) radioligands for the detection of endogenous serotonin release will enable the investigation of serotonergic deficits in many neuropsychiatric disorders. The present study investigates how acute challenges that aim to increase or decrease cerebral serotonin levels affect binding of the serotonin 2A receptor (5-HT_2AR) agonist radioligand [¹¹C]Cimbi-36. In a randomized, double-blind, placebo-controlled, three-arm design, 23 healthy volunteers were PET scanned twice with [¹¹C]Cimbi-36: at baseline and following double-blind assignment to one of three interventions (1) infusion of the selective serotonin reuptake inhibitor (SSRI) citalopram preceded by oral dosing of the 5-HT_1AR antagonist pindolol, (n = 

SUBMITTER: da Cunha-Bang S 

PROVIDER: S-EPMC6459901 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature