Dataset Information
Signal-induced PARP1-Erk synergism mediates IEG expression.
Ontology highlight
ABSTRACT:
SUBMITTER: Cohen-Armon M
PROVIDER: S-EPMC6459926 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Signal-induced PARP1-Erk synergism mediates IEG expression.
Signal transduction and targeted therapy 20190412
A recently disclosed Erk-induced PARP1 activation mechanism mediates the expression of immediate early genes (IEGs) in response to a variety of extra- and intracellular signals implicated in memory acquisition, development and proliferation. Here, we review this mechanism, which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the nucleus. This binding maintains long-lasting synergistic activity of these proteins, which offers a new pattern for targete ...[more]