Dataset Information

Clinical Prediction Score for Community-Onset Bloodstream Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella Species.

ABSTRACT:

Background

This study aimed to identify the predictors and build a prediction score for community-onset bloodstream infections (CO-BSIs) caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella species.

Methods

All CO-BSIs caused by E. coli and Klebsiella species from 2012 to 2015 were grouped into derivation (BSIs from 2012 to 2014) and validation (BSIs in 2015) cohorts. A prediction score was built using the coefficients of the multivariate logistic regression model from the derivation cohort.

Results

The study included 886 CO-BSIs (594 and 292 in the derivation and validation cohorts, respectively). The independent predictors of CO-BSIs caused by ESBL-producing E. coli and Klebsiella species included: 1) identification of ESBL-producing microorganisms from any clinical culture within one year of admission, 2) beta-lactam or fluoroquinolone treatment within 30 days (with 2 or more courses within 90 days; with 1 course within 90 days), 3) hospitalization within one year, 4) the presence of an indwelling urinary catheter at the time of admission. The area under the curve (AUC) of the clinical prediction score was 0.72 (95% confidence interval [CI], 0.68-0.77). In the validation cohort, the AUC was 0.70 (95% CI, 0.63-0.77).

Conclusions

The results of this study suggest a simple and easy-to-use scoring system to predict CO-BSIs caused by ESBL-producing E. coli and Klebsiella species.

SUBMITTER: Kim M

PROVIDER: S-EPMC6460111 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Clinical Prediction Score for Community-Onset Bloodstream Infections Caused by Extended-Spectrum Beta-Lactamase-Producing <i>Escherichia coli</i> and <i>Klebsiella</i> Species.

Kim Moonsuk M Song Kyoung Ho KH Kim Chung Jong CJ Choe Pyoeng Gyun PG Park Wan Beom WB Bang Ji Hwan JH Kim Eu Suk ES Park Sang Won SW Kim Nam Joong NJ Oh Myoung Don MD Kim Hong Bin HB

Journal of Korean medical science 20190415 14

<h4>Background</h4>This study aimed to identify the predictors and build a prediction score for community-onset bloodstream infections (CO-BSIs) caused by extended-spectrum beta-lactamase (ESBL)-producing <i>Escherichia coli</i> and <i>Klebsiella</i> species.<h4>Methods</h4>All CO-BSIs caused by <i>E. coli</i> and <i>Klebsiella</i> species from 2012 to 2015 were grouped into derivation (BSIs from 2012 to 2014) and validation (BSIs in 2015) cohorts. A prediction score was built using the coeffici ...[more]

PMID: 30977317

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