MRI Radiomic Features Are Independently Associated With Overall Survival in Soft Tissue Sarcoma.

ABSTRACT:

Purpose

Soft tissue sarcomas (STS) represent a heterogeneous group of diseases, and selection of individualized treatments remains a challenge. The goal of this study was to determine whether radiomic features extracted from magnetic resonance (MR) images are independently associated with overall survival (OS) in STS.

Methods and materials

This study analyzed 2 independent cohorts of adult patients with stage II-III STS treated at center 1 (N = 165) and center 2 (N = 61). Thirty radiomic features were extracted from pretreatment T1-weighted contrast-enhanced MR images. Prognostic models for OS were derived on the center 1 cohort and validated on the center 2 cohort. Clinical-only (C), radiomics-only (R), and clinical and radiomics (C+R) penalized Cox models were constructed.

SUBMITTER: Spraker MB 

PROVIDER: S-EPMC6460235 | biostudies-literature | 2019 Apr-Jun

REPOSITORIES: biostudies-literature