Nickel exposure reduces enterobactin production in Escherichia coli.

ABSTRACT: Escherichia coli is a well-studied bacterium that can be found in many niches, such as industrial wastewater, where the concentration of nickel can rise to low-millimolar levels. Recent studies show that nickel exposure can repress pyochelin or induce pyoverdine siderophore production in Pseudomonas aueroginosa. Understanding the molecular cross-talk between siderophore production, metal homeostasis, and metal toxicity in microorganisms is critical for designing bioremediation strategies for metal-contaminated sites. Here, we show that high-nickel exposure prolongs lag phase duration as a result of low-intracellular iron levels in E. coli. Although E. coli cells respond to low-intracellular iron during nickel stress by maintaining high expression of iron uptake systems such as fepA, the de

SUBMITTER: Washington-Hughes CL 

PROVIDER: S-EPMC6460284 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature