Acute oral toxicity evaluation of extracts of Hydrocotyle sibthorpioides in wister albino rats as per OECD 425 TG.

ABSTRACT: Hydrocotyle sibthorpioides (Family: Apiaceae) is a medicinal plant and is been a part of traditional cuisine. Hence, an acute toxicity study was performed to confirm its safety profile. Female rats (n=5) were randomly divided into 5 groups. One group served as the control and the other groups were been administered with the petroleum ether, chloroform, methanolic and aqueous extract of Hydrocotyle sibthorpioides at 2000 mg/kg body weight. Blood was collected at certain intervals to measure the haematological and biochemical parameters. The vital organs were isolated and preserved for histopathological examinations. The result suggested that the LD₅₀ of all the extracts are greater than 2000 mg/kg body weight. There was no significant change in body weight, Behaviour, Rena

SUBMITTER: Hazarika I 

PROVIDER: S-EPMC6460325 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature