Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies.

ABSTRACT: Endocannabinoid signaling is implicated in an array of psychopathologies ranging from anxiety to psychosis and addiction. In recent years, radiotracers targeting the endocannabinoid system have been used in positron emission tomography (PET) studies to determine whether individuals with psychiatric disorders display altered endocannabinoid signaling. We comprehensively reviewed PET studies examining differences in endocannabinoid signaling between individuals with psychiatric illness and healthy controls. Published studies evaluated individuals with five psychiatric disorders: cannabis use disorder, alcohol use disorder, schizophrenia, post-traumatic stress disorder, and eating disorders. Most studies employed radiotracers targeting cannabinoid receptor 1 (CB₁). Cannabis users c

SUBMITTER: Sloan ME 

PROVIDER: S-EPMC6460371 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature