Spatiotemporal Modeling of the Key Migratory Events During the Initiation of Adaptive Immunity.

ABSTRACT: Initiation of adaptive immunity involves distinct migratory cell populations coming together in a highly dynamic and spatially organized process. However, we lack a detailed spatiotemporal map of these events due to our inability to track the fate of cells between anatomically distinct locations or functionally identify cell populations as migratory. We used photo-convertible transgenic mice (Kaede) to spatiotemporally track the fate and composition of the cell populations that leave the site of priming and enter the draining lymph node to initiate immunity. We show that following skin priming, the lymph node migratory population is principally composed of cells recruited to the site of priming, with a minor contribution from tissue resident cells. In combination with the YAe/Eα system, we

SUBMITTER: Hayes AJ 

PROVIDER: S-EPMC6460458 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature